Poverty Is A Global Issue - 2393 Words

Every city has poverty. Travel around the world, I bet it wouldn’t be difficult to find a city that doesn t have an impoverished community. Poverty is a global issue, but most importantly it’s a local issue to me in the city that I live in. Among the 10 largest cities in America, Chicago has the third highest poverty rate with 40-60% of our residents living under the poverty level. People who live in poverty are given less opportunities, resources and tools than people who live in the middle or upper class. Poverty is not a pleasant subject, however, poverty is real. In the daily lives of the poor, poverty becomes a network of disadvantages. The end result is that there is a lack of access to education, employment, health care, affordable housing, proper sanitation and good nutrition among many generations of the poor (End Poverty). Of the issues associated with poverty, the lack of access to an education stands out to me the most. In Chicago, education is greatly valu ed and is vital for all development and growth achievements in people. Education is the process in which people gain knowledge, help form and shape attitudes and opinions, and allow people to gain a set of skills that they can further use in areas outside of a school environment. However, education systems in Chicago are taking a huge deficit due to the effects of poverty. The effects of poverty are already big factors toward the concern about Chicago, and why it is portrayed as negatively as it is, but thoseShow MoreRelatedPoverty Is A Global Issue1448 Words   |  6 PagesPoverty is a global issue known by many people, it affects people in many ways, and can be considered a constant battle. The war on poverty has been ongoing for many years not only in the United States, but also amongst various countries. A significant country dealing with poverty is South Africa, which has struggled to provide jobs, education, and social security, to its people for numerous years. Moreover, th e same applies to countries like the United States. Our first impression is that the UnitedRead MoreWorld poverty is a complex global issue that varies depending on where you live. Many Americans1900 Words   |  8 PagesWorld poverty is a complex global issue that varies depending on where you live. Many Americans take for granted shelter, food, and water. While, in third world countries these three elements are difficult to obtain for the necessities of their survival. Unless there is a cultural and behavioral change in our society regarding world poverty, poverty rates will continue to rise. Poverty is affecting thousands of people in the United States; this impact is changing the quality of life for familiesRead MorePoverty : An Effective Means Of Population Control897 Words   |  4 Pagesless fortunate and how they get there. As we learn more about the poverty-stricken, we can understand them better to aid them and break the cycle. Overwhelming amounts of people do not real ize the global pandemic that poverty is today. The statistics are heartbreaking. Over half of the children in the world live in poverty, and there are nearly 2.2 billion children in the world. Campaigns have been established to recognize poverty globally. The effectiveness of these campaigns remains relativelyRead MoreExtreme Poverty : Chronic Poverty Essay1613 Words   |  7 PagesExtreme Poverty Nathan Larson Northcentral Technical College â€Æ' Introduction ïÆ'Ëœ What is Extreme Poverty? What if you had a chance to save a person? Most would react quickly if given the chance to save another life especially a child’s life. In fact, it is estimated that 16,000 under the age of five die every day due to causes associated with extreme poverty. That is nearly 750 children an hour. The causes of the deaths include insufficient nutrition, lack of access to clean water, no health careRead MoreGlobal Health Organization System Of The United Nations1353 Words   |  6 PagesIntroduction Global health care continues to evolve as countries develop and also improve medical technology and treatments for diseases. Medical teams from developed countries continue to work in developing countries to treat patients and train locals with the medical skills they will need in order to help those in their community. The World Health Organization (WHO) is constantly monitoring and taking the lead when it comes to providing the health care that so many countries desperately needRead MoreWhich Do You Think Would Help The Citizens Of The WorldS Poorest Nations More, Increasing Foreign Aid Or Removing All The Agricultural Tariffs And Subsidies?1069 Words   |  4 Pagesor removing all the agricultural tariffs and subsidies? The latter would help them more. Heres why, in researching global poverty one can come across startling statistics, e.g. almost half the people in the world live on less than $2.50 a day (Shah, 2011), 1 out of every 2 children live in poverty (Shah, 2010); spea king of children, 1 child will die every 4 seconds due to poverty, easily preventable diseases and illnesses, and other related causes (Shah, 2010), the GDP of the 41 Heavily IndebtedRead MoreImpact of Agricultural Trade liberalization on Poverty in Latin America1300 Words   |  6 Pagesliberalization on Poverty in Latin America Historically the agricultural sector has been an important sector for the economies of Latin America because of this the issue of global agricultural trade liberalization has been a hotly contested issue. Some suggest it may harm Latin American countries and increase poverty by opening up the sector to foreign competition from more technological advanced nations. Others have argued that it will increase economic competitiveness and reduce poverty by promotingRead MorePoverty And Poverty1721 Words   |  7 PagesOver the years, poverty has become an issue that is growing drastically and more people are starting to succumb to it and are falling below the poverty line. Poverty is like an epidemic that is constantly spreading because it has many causes to it. Poverty is the faceless enemy that exists in today’s society and targets those who are incapable of fighting against it and those who cannot support themselves. It is a never-ending nightmare of living life in hunger, with out shelter, being exposed toRead MoreGlobal Poverty Essay example1162 Words   |  5 PagesPoverty has become a crucial fact worldwide and has a great influence on economic development. Foreign aid from wealthy regions has been dedicated to reducing poverty. Before delving into the argument, it is necessary to clarify the term â€Å"western countries† and â€Å"global poverty†. Western countries refer to the most developed countries which have in common a high standard of living for most of the residents, such as the United States, most European countries and Australia. Global poverty in this essayRead MoreThe Global Politics Of The United States And The European Union1667 Words   |  7 PagesThe global politics in today’s world is characterized by the dominance of the United States and the European Union, and the rising power of China enabled by its rapid economic development. Since the conclusion of the Second World War in 1945, no conflict has occurred o n a global level. Despite some regional warfare, the world after 1945 has provided many countries with a relatively stable environment for development. Various advancements in technology have flourished in this environment, such as

The Crucible Research Paper Free Essays

John Doe The Crucible Research Paper Around the same, beginning in the 1940’s, both McCarthyism and the imprisoning of the Japanese after Pearl Harbor were taking place. Senator Joseph McCarthy went house to house searching and questioning people he believed were communist. If you were accused of being communist you were put on a list called the â€Å"red-list†, which meant that your passport was taken away, your job was at stake or you were sent to jail. We will write a custom essay sample on The Crucible Research Paper or any similar topic only for you Order Now Immediately after Pearl Harbor was attacked, the President declared that everyone of Japanese decent could be a possible threat to the American people. The Japanese families all over the nation were sent to internment camps, much like those of the Holocaust. The fortunate ones were told to pack one suitcase and leave their homes and move to their new location, given by the government of course. McCarthyism and the Japanese Internment Camps have several similarities and a few differences. To begin, in both cases, the subject at hand was blown out of proportion with inadequate evidence against both the so-called communists and the supposed Japanese spies. â€Å"McCarthy’s relentless pursuit of communist ‘subversives‘ took the witch-hunt to new heights. After the cold war, the threat of communism intensified. Several people, including celebrities, were red-listed. There was absolutely no proof that these people were even communist. After the attack on Pearl Harbor, President Franklin Roosevelt was convinced that there were Japanese spies here in America. Again, with no factual evidence that these people of Japanese decent were spying for Japan, they were all taken from their homes and places in internment camps or moved to a different location with no explanation. The US justified their action by claiming that there was a danger of those of Japanese descent spying for the Japanese. † To wrap up, during McCarthyism and the Japanese Interment Camps, both were prisoned unfairly without evidence or trial. Secondly, the two topics at hand differed because with the Japanese, the only people that were moved and or imprisoned were those of Japanese decent, but with the red scare, anyone could possibly be accused. During the time the Japanese were being sent to the internment camps, under the order of President Roosevelt, everyone knew what was going on and exactly who the accused were. On the contrary, while McCarthy was persistently hunting for those who could possible be communists with the thought of overthrowing our Republic, none of the common people knew who or when the next ‘communist’ would be red-listed, or maybe jailed. Mad chaos went through the county in both cases. To conclude, both McCarthyism and the Japanese Internment camps compared and contrasted in a few ways. In both time periods, people were jailed without any proof that they were guilty, chaos was insane due to the random imprisonment of loved ones and friends. However the two contrasted because during McCarthyism several people of many different ethnic backgrounds were red-listed and when the Japanese were being sent to internment camps or relocated, specifically the Japanese were targeted. Works Cited â€Å"History Study Center – Home Page. † History Study Center – Home Page. N. p. , 2002. Web. 27 Nov. 2012. â€Å"Internment History. † PBS. PBS, n. d. Web. 29 Nov. 2012. Miller, Arthur. â€Å"McCarthyism. † PBS. PBS, 23 Aug. 2006. Web. 26 Nov. 2012. â€Å"World War Two – Japanese Internment Camps in the USA. † World War Two. N. p. , 10 Sept. 2012. Web. 30 Nov. 2012. How to cite The Crucible Research Paper, Essays

Guidance Sheet for Applicants Intending to Work in the Usa free essay sample

Mention your Name and Passport number on the reverse side of the demand draft. Principal Applicant 1. Current old Passports, original green visa fee receipt issued by HDFC bank, CEAC Bar code confirmation letter and VFS Interview appointment letter. 2. L1 Blanket Visa applicants are required to pay the $500 as FPD fee via demand draft amounting to Rs. 23500/-(at current rate of exchange) favouring â€Å"US Embassy, New Delhi† or American Consulate General, Chennai or Kolkata or Hyderabad† as applicable. DDs drawn on co-operative banks are not accepted. . Under Public Law 111-230 requires an additional fee of $2,250 for covered L-1A and L-1B petitions and $2, 000 for covered H-1B petitions. This fee is in addition to the base processing fee and the existing Fraud Prevention and Detection Fee required for a Petition Nonimmigrant Worker. For more information please visit http://www. uscis. gov/ 4. The original Notice of Action (Form I-797). 5. If Form I-797 is a blanket petition, copy of Form I-797 and original Form I-129 as well as an original letter from employer that describes your proposed duties. We will write a custom essay sample on Guidance Sheet for Applicants Intending to Work in the Usa or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Original letters verifying your employment history and specific work skills. 7. Original degree certificates along with mark sheets. 8. Relevant diplomas or certificates, e. g. computer certification. Spouse / Dependent Children 1. Current old Passports, original green visa fee receipt issued by HDFC bank, CEAC Bar code confirmation letter and VFS Interview appointment letter. 2. The original Notice of Action Form I-797 of the Principal Applicant. 3. If Form I-797 is a blanket petition, copy of Form I-797 and original Form I-129 as well as an original letter from employer that describes your proposed duties. Applicants scheduled for the appointment under the visa renewal programme must carry the original passport with the previous visa stamp. Photocopies of old visas will not be accepted.   Applicants scheduled for interview at Mumbai Consulate ONLY) A comfortable air conditioned waiting facility is available for visa applicants and accompanying people. Please check our VFS website www. vfs-usa. co. in for more information on the services and charges. The information is subject to change without notice. Please check the VFS website at www. vfs-usa. co. in for latest information before your interview date. You can also email us If you belong to Chennai Consular District email us at [emailprotected] om If you belong to New Delhi Consular District email us at [emailprotected] All battery operated or electronic gadgets such as mobile phones, digital diaries, digital watches, pagers, cameras, audio/video compact discs, MP3s, floppies, laptops, cassettes, palmtops or portable music players. 2. All ladies hand bags/purses. Only a small ladies pouch in hand will be permitted. 3. All bags such as travel bags, back packs, briefcases, suitcases, leather, jute or cloth bags and zip folders. Only a plastic bag containing your application-related papers will be permitted. Ordinarily the passport will be returned to VFS within 72 working hours from the interview date. Delivery time lines depend on place of residence. 2. You can check passport delivery status by logging on to www. vfs-usa. co. in or by sending an SMS message â€Å"VISA US (passport number)† to 57333. 3. Counter Passport Collection: you have the OPTION to collect your passport across the counter in the city where your interview was held. Passports may be collected on the day the visa section hands over your passport to VFS. The collection timings are: 1. Chennai VFS centre – 16:00 to 17:00 hours. 2. Mumbai VFS centre – 17:00 to 17:30 hours. 3. New Delhi VFS centre – 16:00 to 17:00 hours. 4. Kolkata VFS centre – 14:30 to 16:00 hours. 5. Hyderabad VFS centre – 15:00 to 16:00 hours. 4. Please check the ‘Track Your Passport’ link on our website (www. vfs-usa. co. in) for information on the documents required by you or your representative when collecting the passport from VFS Application Centre. 5. You will need to show the original fee receipt issued by HDFC Bank and the interview appointment letter. Passports not collected across the counter the same evening will automatically be dispatched by courier. Important to Note: (a) Passport will NOT be delivered across the counter at the U. S Embassy or Consulate. (b) The time taken for a visa section to hand over the passport depends on the circumstances such as work load, intervening holidays etc. Hence, a definite turnaround time cannot be assured. 6. Kindly check the details on your visa before travel. IF YOU ARE DENIED A VISA: The Consul will return you your passport after the interview.

This is my introduction to the brain and spinal co Essay Example For Students

This is my introduction to the brain and spinal co Essay rd. I will tell you where they are located and what they do in my own words. Listen and read. The spinal cord is located on your lower back. It is made out of a big bundle of neuron and the purpose is to allow you to move. It helps you work, sleep and do things in todays world. The brain controls every thing in the body. It is in the top layer of your skull with jelly mass and has three parts. Thats the end of the introduction of the spinal cord and brain. One of the parts of the nervous systems is the brain. The brain belongs to the section of nervous systems called the central nervous system or C.N.S. It is at the top of your head inside your skull. This soft jelly like mass has three parts. These three parts are called the cerebrum, cerebellum, and the medulla or brainstem. The function of the cerebrum is to control voluntary action, which includes speaking, the five senses, movement, memory, and thinking .Thc second major part of the brain is the cerebellum. The cerebellum commands balance coordination and posture. The last major part of the brain is the medulla it is in charge of heartbeat digestion, breathing sleeping and being awake. These are all the involuntary function of the body This part of the brain is the connector between the spinal cord and the cerebrum. The spinal cord belongs to the C.N.S. It is the most important bones of your lower back and it controls movement and mostly every thing in the body it has nerves. If you do not have a spinal cord you cant move around and go anywhere. You can not work or you cannot do most things normal people do. That is why you need a spinal cord to live in todays world. We will write a custom essay on This is my introduction to the brain and spinal co specifically for you for only $16.38 $13.9/page Order now The five senses belong to the Peripheral Nervous System. They are the skin,which is the largest organ in the body,located all over the body.Ears located R/L side of the head above the jaw. Eyes located R/L side of the nose. Nose located at the center of the face between your eyes above the mouth. Tongue located inside your mouth below the nose and above the chin. The function of each of the sense organs are,your nose is for smelling. The tongue is for taste. The skin it lets you feel things. Eyes lets you see things like your eye sight. Ears lets you hear sounds. The Neuron belongs to the P N S .Neurons are located every where in your body. The five parts are the cell body and the dendrites,neurontransmitter and nucleus and axon.The cellbody is the main part of the cell. Dendrite is the receiving part of the neuron. Neurotransmitter message carrying chemistry. Nucleus is the brain of the neuron. Axon carries the message to the next neuron, which controls all of the nerves. In conclusion the nervous system is the controling part of the body. The neurons also has two sections and four parts. The two sections are the central nevous system is the brain, spinal cord, neurons, and the five senses. That is the closing of the nervous system.

After the First Death Analytical essay essays

After the First Death Analytical essay essays In the novel, After the first Death, it exposes the consequences of guilt and betrayal quite a few times throughout the story. The consequences of guilt and betrayal vary from small, to quite large and serious matters in this novel, the more serious matters towards the end of the novel, where it results in a lot of people being killed due to these elements. A serious experience in the novel that shows acts of betrayal, to not only the person himself, but also to his companions and country. The first act of betrayal takes place in chapter eleven, during the scene where the military are preparing an assault on the bridge and bus, and the terrorists have got General Marchands son, Ben, in integration. During the integration scene, where Ben Marchand gets tortured by Artkin, the terrorist leader of the operation, and is forced to tell him all of the information about the militaries operations and tactics they plan on implementing. To Ben, telling this information, even though it is false information that his father lied to him about, Ben thinks that he has betrayed not only himself, but his father, General Marchand, his family, the people on the bus, and most of all, his beloved country. Another act of betrayal also takes place in this same chapter, eleven, when the military finally decide to attack and storm the bridge from above, assaulting from helicopters, and from the sides of the bridge. Deciding that they have to bail from the operation, Miro and Artkin decide to escape, so they can live on to carry out other operations. Miro grabs Kate, the bus driver, by the arm and drags her out of the bus, while Artkin grabs Ben from the van and drags him out onto the bridge as well. Once they our out of the vehicles and onto the bridge, the noise from the guns firing, grenades going off and the helicopter make verbal communication very difficult for Miro and Artkin, and Miro notices the soldiers that are closing in fast on them, a ...

Acropolis Museum

Acropolis Museum The (new) Acropolis Museum opened its doors to the public in June 2009 and is an important reference point for culture and consequently for the cultural law. The location of the museum, as well as the way of the exhibition practice, aims at collecting, protecting, studying, highlighting, and displaying the monuments of the sacred rock of Acropolis at national and international level. It is a museum specially dedicated to the monuments of the Acropolis. Among its missions, the museum focuses on making accessible to its visitors, scientists, and anyone interested the world-class archaeological treasures. It contributes to the promotion of historical and archaeological knowledge, aesthetic cultivation, creative thinking, and -in general- modern perception of classical education. The purpose of the Museum is to coordinate all its functions according to the visitor and his expectations. The institution seeks in many ways to make the guest a real shareholder in its research programmes for interpretation and understanding of the exhibits. The organization is an element that proves the museum orientation in the modern form of communication of the cultural institutions focusing on the visitor. Cultural organizations play a crucial role in our society, economy, and cultural life of every country. In an environment that is particularly competitive and difficult, all the cultural institutions should search for ways and tools to make themselves sustainable. Undoubtedly, communication is a fundamental function of museums and above all with the public. It should transmit and provide with information, messages, and experiences in a clear and effective way to different and diverse audiences. Through communication, the public image of the organization is also determined. The Acropolis Museum gives emphasis on its communication strategy. It includes the Front of House Department whose role is to ensure the smooth reception of the audience and flow of visitors, create a hospitable environment, and provide high-quality services. The Communications and Promotion Department is responsible for supporting and promoting the museum in Greece and abroad. Development and protection of the museum’s successful external communication include -among other things- the official website, Facebook page, Youtube channel, web newsletters, publications, written communication with the wide public and the media. This case study The Parthenon Gallery fully reflects the content of the organization as its architectural structure and exhibition practice aims at the balanced relationship between the museum and monuments of Acropolis and; the unique ability of visitor to connect comfortably and in a multiple ways the architectural sculptures with the ancient temple where they come from. The relationship of the building with the surrounding area is one of the biggest advantages of the exhibition.

Smoking among Teenagers Research Paper Example | Topics and Well Written Essays - 2000 words

Smoking among Teenagers - Research Paper Example Not only this but also a teen’s exposure to cigarette smoke increases the risk of metabolic syndrome. Smoking during the teenage impacts the teenager’s overall health, lung efficiency, reduces concentration span as a result of which his or her academic performance is hampered. Youth is that period of our lives where our mind and body are at their peaks but smoking during teenage deprives one of giving one’s best performance in all walks of life (Hales, 2009-2010). The hazards of teenage smoking and its causes can be traced to the determinants of health as per the ecological model. THE ECOLOGICAL MODEL The ecological perspective on health includes individual and environmental factors. The ecological model stresses that for community assessment, it is important to look beyond individual factors and also incorporate organizational and community factors. As per the ecological model, behavior at the individual level is influenced by biological, physiological, psycholo gical and emotional states. The psychological aspect of teenage smoking is that teenagers have it at the back of their mind that smoking makes them more ‘cool’ and mature. Many a times a teenager tries the first puff just to imitate his or her favorite celebrity. The social and cultural beliefs of family, friends and peers comprise of the interpersonal level. Smoking behavior of a teen is influenced by family: for instance if one of the parents smokes, then the child tends to smoke too. Heredity is the main biological factor: for instance women who smoke during pregnancy are indirectly making their unborn children prone to nicotine. These children develop a liking for nicotine and also show quick addiction. Friends are part family members and usually a teen is more influenced by friends than by his family. Many teenagers testify that their friends forced them to take the first puff (Harris, 2010). The physiological factors for teenage smoking will include nicotine metab olism and excretion. Cultural beliefs are very correctly depicted in the promotions of the Marlboro Man (McLeroy, 1988). At the organizational and community level, economic, physical and structural factors influence behavior. This level encompasses educational programs, mass media, counseling, support groups and organizational incentives. Public policy is another domain at which assessment can be done for a community. The Public Policy shows the state’s stance on health and related issues. For instance public service messages against teenage smoking and awareness programs come under public policy. Not only this but also public policy includes national laws for teenage smoking like a ban on selling cigarettes to a minor (Harris, 2010). Relationships with family, friends, neighbors, contacts at work, and acquaintances form the interpersonal processes which influence health behaviors. These relationships are particularly more influential in a teenager’s life as his mind i s vulnerable and he tends to adopt common behavior in his surroundings. The way a teenager deals with stress is also influenced by these relationships. If an adult smokes excessively during stress than his teenage son would do the same under stress. If the same interpersonal relationships can provoke a teenager to smoke then they can also work as support systems in times of stress and rehabilitation (for smoking or alcohol addicts). However if a

Freedom of Expression in the Workplace Case Study

Freedom of Expression in the Workplace - Case Study Example .This, however, does not mean that there is no adequate protection for employees. The Anti-discrimination laws provide for a level of protection for certain types of expression made in a workplace setting, which is not necessarily a First Amendment right (Sutherland, 1). Despite these laws, there is still a problem as to the amount of power that employers hold as regards the freedom of expression or expressive activities of employees which may hinder employees’ rights (Whitaker, 1). To address this problem, Bruce Barry in his book entitled â€Å"Speechless,† suggests that there must be changes made as to the laws and to management practice that would expand or develop the expressive rights of employees without however jeopardizing or compromising the interests of the employer (Barry, 1). Businesses should also have a code of conduct where there should be respect for expressive activities of employees, which may pertain to respect for an employee’s religion or expressions which tend to discriminate or harass a person’s race or sex (Whitaker, 1). In order to ensure the free expression of workers without however jeopardizing employer’s interests, there must be some monitoring.

Experiment to investigate what affects the size of a crater Essay Example for Free

Experiment to investigate what affects the size of a crater Essay Hypothesis: If the height of which the pendulum ball is dropped increases, then the depth of the crater will increase. There is a theory for this. A higher drop would mean that there is a greater gravitational potential energy. When the ball is dropped, all this energy is converted into kinetic energy and it is used up to create a crater in the ground. Variables: 1. Independent: Height at which the pendulum ball is dropped from A one meter ruler is used to measure the height at which the pendulum ball is dropped from the surface of the sand. Each height is recorded down and tabulated together with the results. 1. Dependent: Depth of the crater A vernier caliper is used to measure the depth of the crater. Push out the bottom until it touches the center of the bottom of the crater. Adjust it until the edges of the caliper touches the surface of the sand. Read the measurement and record it down. Results are tabulated. 1. Controlled: Height of the sand, Volume of the sand, diameter of the pendulum ball Height of sand is measured with the same ruler used in the experiment and marked out with a marker. The volume of same is measured by pouring it into a beaker and then weighed on an electronic weighing balance for further accuracy. The diameter of the pendulum ball was measured before the start of the experiment and noted down. Apparatus: 1. Pendulum Ball x 1 2. 1m Ruler x 1 3. Plastic box x 1 4. Sand 5. 500ml Beaker x 1 6. Vernier Caliper x 1 7. Retort stand 8. Whiteboard Marker 9. Tissue Method: 1. Lay out newspaper on the bench/work area 2. Measure out 250cm3 of sand using the beaker 3. Pour the sand into the plastic container 4. Smoothen the sand with a tissue so that it is leveled 5. Measure the height of the sand and mark it out with the marker on the container 6. Set up the rest of the experiment as drawn on the previous page. 7. Hold the pendulum ball at a height of 10cm with the bottom of it on the 10cm mark 8. Drop the pendulum ball onto the sand 9. Remove the pendulum ball carefully so as not to destroy the crater made in the sand 10. Using a vernier caliper, measure the depth of the crater 11. Record the reading down 12. Repeat steps 4-10 for heights of 20cm, 30cm, 40cm, 50cm, 60cm, 70cm, 80cm, 90cm and 100cm 13. Repeat the whole experiment once Results: Height/cm Depth/cm 1st 2nd Average Evaluation Reliability of method: From the table of results, it can be observed that some results in the first set of data differ greatly from the second set. This shows that the current method is not extremely reliable and changes can be made to improve the experiment. An improvement to the method would be to always measure the volume of the sand used and smooth it down to the marked level on the side of the container. Sand that is not compacted may have a different result from compacted sand. This is because between the particles of non-compacted sand, there will be spaces of air. As the pendulum ball hits the surface of the sand, the kinetic energy will disperse into these spaces. Therefore, a smaller crater would be formed because the pendulum ball has less energy. Validity of method: The method is valid because it measures what is required to be measured in the experiment. The method described above was also followed step-by-step. The volume of the sand and height of the sand is unchanged. The pendulum ball remained unchanged throughout the course of the experiment as well. The vernier caliper measures the depth of the crater in centimeters and it is what the experiment is conducted for. Reliability of results: There are a total of 20 sets of data. The number of data collected makes the results reliable. Also, the average of the data from both sets of experiments were able to form a straight line graph with an outlier for 100. 0cm at 1. 77cm. Therefore, the results of this experiment is somewhat reliable. Analysis The graph is a straight line with increasing gradient. It shows that with an increase in height, the average depth of the crater also increases. The line graph does not pass through the origin (0,0) because the graph paper is too small to accommodate 10 sets of results (average of both sets of data). Conclusion The results of the experiment support the hypothesis. When the height at which the pendulum ball increases, the depth of the crater also increases. This is proven by the fact that the greater the distance between the ball and the ground, the greater the gravitational potential energy that the ball possesses. More gravitational potential energy is converted to more kinetic energy when the ball is dropped. As such, there is more energy to cause a greater damage to the ground, or in this case, sand, therefore resulting in an increase of depth of the crater. Limitations and Improvements Limitations Improvements Pendulum ball does not drop straight down directly from where it is released but deviates from its desired path Drop the pendulum ball using a retort stand instead of by hand Removing the pendulum ball by hand Thread a string through the hole in the pendulum ball and lift it out of the sand using that.

How Nadine Gordimer Ends Her Stories Essay -- Nadine Gordimer An Intru

How Nadine Gordimer Ends Her Stories Nadine Gordimers stories make enormous demands upon the reader. Mostly on the first reading it’s even hard to know what’s actually going on. But gradually a densely concentrated image or an idea will develop after reading over the story again and concentrating on some particular parts, like for example the endings. Indeed you should pay much attention to them. Even through nearly every of them are slightly different, they indicate what you should think about and leave you with a curious eagerness to find out more, to get to know what happens next. In fact I am sure that Nadine Gordimer just wants us to make our mind work and mull over the main meaning of the story, to uncover what she wants to express with it. In many cases, the conclusion of the story is what impresses you most. Some writers don’t realise this fact and they destroy the whole piece of work by an unsuitable ending. But Nadine Gordimer’s conclusions are marvelous. If you would miss it you won’t be able to get the point of the story because it encompasses much very important information. For example in the story â€Å"An Intruder† one of the main characters goes through a drastic change in last four lines. â€Å"She stood there wan, almost ugly, really like some wretched pet monkey shivering in a cold climate† (p. 374) This is a big contrary because throughout the whole story she was the described like a â€Å"frail little marmoset† (p. 367) and as â€Å"beautiful† (p.369). However she changes in the end â€Å"... she was grown-up, now, suddenly, as some people are said to turn white-haired overnight.† If the reader would miss this significant change in her life, he probably would not find out what the story is actually about... ... try to argue that the story ends in a fortunate way for Ella because she goes to Europe, and that’s what she was dreaming about for so long. But we have to become aware of what preceded the trip – a cruel murder, and we even don’t know if Ella is truly happy or if she enjoys the trip at all. A good way of making people think and wake their interests is to irritate them, exactly in that way how Gordimer irritates her readers with the endings. How could be Marie so blind and immature for ages and than grow up â€Å"in a second†? How is it possible that a system is SO unfair and unjustly like in case of Ella and Lena? And how does the narrator of â€Å"Africa Emergent† even dare to make him innocent for Elias’ death? Simply said, Nadine Gordimer is that kind of writer that can give a true picture of what’s going on, and can make it very interesting to the reader.

Modern Myths

Modern myths still pervade North American societies. Many of these modern myths were the products of Indian folklore or pre-modern American society. Although many claimed that such myths were a form of religious fanaticism or fervor, it can be argued that they were the result of historical speculation of early North American societies of their immediate environment. These modern myths are nonetheless powerful and to some extent influenced the behavior of many noted American personalities. Here is an example of a modern North American myth.Urban Legend: Bloody Mary (Schlosser, 2006)There was a young woman who sleeps deep in the forest. Her livelihood was selling herbal medicines in a nearby village. The townspeople though regarded her as a witch; hence no one dared to approach her, even the hardest criminal in the area. Many believed that whoever talk or approach her would be cursed or sold to the devil. She was feared indeed. Then, little girls in the town began to disappear. No trac es of the girls were found. Families of the disappeared girls began to search; in the farms, barnyards, and even the forest. Some of the men went to the house of Bloody Mary, but altogether she denied all allegations.The men noted that Bloody Mary looked younger and more attractive. They became suspicious of Bloody Mary, although no proof cold be found. Then one night, the daughter of the miller rose from her sleep and began to walk outside as if following an incantation. The wife of the miller saw the incident and reported it immediately to her husband. The two restrained the girl indiscriminately in order to prevent her from breaking away. Many people were awakened by the cries of the couple. Then, a farmer shouted that the cause of the incident is coming from the woods.Then, some people saw Bloody Mary holding a magic wand pointed to the house of the miller. When Bloody Mary saw the angry townspeople, she fled to the woods. A keen shooter farmer loaded his gun with silver bullets and shot the witch in the hip. Bloody Mary was carried by the townspeople to the field, where a large bonfire was awaiting her death. As Bloody Mary burned, she screamed a curse. If anyone mentioned her name before a darkened mirror, she would send her spirit to revenge upon them for her death. Unmarked graves of the little girls were found by the townspeople. They learned that Bloody Mary used to drink the blood of her victims to make her young again. It was passed on from generations to generations that whoever chants Bloody Mary three times on a darkened mirror, this would summon the vengeful spirit and rips the body and soul of the person.Social Significance of the Myth (Bloody Mary)The social significance of the myth discussed above can be seen in the various movies and accreditation the myth received from the movie industry. The myth is a powerful tool of revenue creation as with this specific industry. In the past 30 years, there were about 500 versions of this myth, all foc using on the â€Å"horror† part of the film, that is, the darkened mirror and the chanting of the words â€Å"Bloody Mary.† It is of no doubt that because Bloody Mary films became successful ventures, it is right to assume that its basis, the original myth, still exerts considerable influence on the part of the audience.According to the Encyclopedia of Folklore and Literature, urban legends and myths are usually defined as â€Å"apocryphal contemporary stories, told as true and usually attributed to as friend of a friend.† In most instances, the myth of Bloody Mary is perceived to be true by virtue of the fact that the story is assumed to be true by the storyteller. Although the story is non-existential or in short not real, the audience may find it true because of the way the â€Å"channel.† Because the channel presents the story as â€Å"true†, the receiver nonetheless assumes it to be also true.The channel here maybe defined as â€Å"the means of acquiring the information about the particular myth or urban legend (as in this case).† Movies and bonfire storytelling are the most efficient and effective means of transmitting the myth from one person to the other, without losing the track of credibility. It is no wonder that most Bloody Mary films are inconclusive, that is, they left the audience wondering whether the myth was true or not (to make a room for affirmation of the myth). Now it is safe to assume that even in North American societies, particularly in the United States, the myth of Bloody Mary pervades in some aspects of life.Children, particularly girls, are told of the story of Bloody Mary by their parents as a means for exacting obedience (negative reinforcement). For those in their teenage years, the story of Bloody Mary serves as a background check for their behavior.   They prevent themselves from going to forests without the guide of adult individuals. They also stay away from dark places with mirror s for fear that the myth may prove to be true. Although for them, the story of Bloody Mary is factual since there were individuals who reported that they saw Bloody Mary ripping the body of their friends.Going back to the definition of a myth or urban legend, the storyteller assumes that his/her story is true in order for the audience to feel its negative effect (affirmation of the story). There were reported cases when robbers were scared to their â€Å"pants† when they entered a house (without electricity) with a darkened mirror in the entertainment room. There were also reported cases when a man brushing her teeth in a nightclub and jokingly uttered Bloody Mary three times.A face appeared before him. He ran outside the club shouting that Bloody Mary did exist. He promised that he would never visit the nightclub. The woman who appeared to him was a prostitute, not Bloody Mary. This proves that even though the myth is not real, people usually perceives it as real. The primar y cause of such behavior is the channel that make the story real or â€Å"seem real.† The myth is as powerful as before. Although it can be assumed that its effects on the values of an individual may be accidental and in many cases derived from the characters of Bloody Mary films.ReferencesSchlosser, S.E. 2006. Bloody Mary. URL http://americanfolklore.net/folklore/2009/10/bloody_mary.html. Retrieved September 19, 2007.1800 Myths, Legends, and Folklore Links. URL http://www.mysteries-megasite.com/. Retrieved September 19, 2007.

Investigate different ways in which reaction times Essay

Some people have slower reaction times than others. To find this out, I have decided to test some people in my class. We are now going to investigate different ways in which reaction times of people can be measured. Reaction times A reaction time is how long a person takes to react to something. Methods of Testing Reaction Times 1: Time how long it takes to move from one point to another, after being told to start by a blow of a whistle, clap of hands or simply by saying go. 2: Time how long it takes to rise from the blocks in a race. 3: Time how long it takes a person to react when someone instructs them to stand up. 4: Time how long it takes for a person to press a button when a buzzer goes off, record how long the buzzer is ringing for. 5: Time how long it rakes for someone to turn off a light when it starts flashing using an electronic device to time how long it takes for the light to be switched off. 6: Drop a ruler and measure the distance it drops before the person catches it. The class discussed all of the above methods and decided that some would not work and that some wouldn’t be possible due to lack of resources. The class decided to use the same method of measuring reaction times so that we could collect enough data. 1: This method would be very hard to time, as the accuracy of the time would also depend upon the reaction time of the person holding the stopwatch. Also the time taken would not only measure reaction time it would also depend on how fast the person can run. 2: This would be a good method if we had access to Olympic standard equipment, which would measure the time electronically from the sound of the gun to rising from the blocks. 3: This method, just like number 1, would be hard to do. The time again would also depend upon how quickly the person can move to a standing position. The reaction time is how long it takes to begin to stand and this would not be possible to measure. 4: We cannot record this properly as we do not have any stopwatches to make sure we have an accurate reading. 5: This applies the exact same as number 4, we do not have the possible equipment for this method. 6: This is possible as the distance the ruler drops only depends upon the reaction time of the person trying to catch the ruler. After considering all the possible methods, my class decided to use the dropping of a ruler and measuring how far it falls. When we conduct this experiment, the arm will be held out at shoulder length and the ruler will be held between the thumb and the index finger at 0cm. We shall work in pairs, one person will say go and the other person will release and try to catch the ruler with the same hand. The first person will keep a record of the distance the ruler has dropped. We will assume that the longer the distance means greater time.

Management of the BLMs Public Lands System essays

Management of the BLMs Public Lands System essays Management of the BLM's Public Lands System The government has control of over one-third of the nation's land, and 398 million acres of that is controlled by the Bureau of Land Management (BLM 6). This land hold a wide diversity of resources, from timber, and grazing lands found on the surface to a mass of oil, natural gas, and minerals laying below the earth. The history of these lands is hardly a dull story, because it is the story of the taming of the "Wild West". Should the BLM though, still be controlling these lands under the same laws that where put in affect to establish the Western Frontier. I feel that a radical reevaluation of these laws needs to take place, in order to adapt them to the changing demographic and technological environment of our society. The laws that are remaining are allowing companies to hurt the land, which is against the mission statement of the BLM. The BLM mission statement say, the Bureau is responsible for the balanced management of the public lands and resources and their various values so that they are considered in a combination that will best serve the American people. Management is based upon the principles of multiple use and sustained yield; a combination of uses that takes into account the long-term needs of future generations for renewable and nonrenewable resources. These resources include recreation, land, timber, minerals, watershed, fish and wildlife, wilderness, and natural, scenic, scientific and cultural values. (BLM 7). Therefor by allowing these old laws to remain they are pulling away from there mission statement. Throughout the 80's the Bureau of Land Management developed a host of programs and emphasized a number of others - outdoor recreation, wildlife and fisheries, toxic materials management, and wetland enhancement, to name a few - but there are still many problems that must be addressed. Due to the increasing demand for outdoor recreation, there has bee...

NIKE Corporate social responsibility Essay Example | Topics and Well Written Essays - 3500 words

NIKE Corporate social responsibility - Essay Example Corporate social responsibility (CSR) is widely discussed in boardrooms across the world. Of late there have been considerable changes in the corporate value system. This is largely due to both external and internal pressures from various actors and factors in the stakeholders such as government and regulators, consumers and customers, non-governmental organizations (NGO) and in some instances from within the organizations itself (Bhandarkar & Alvarez-Rivero, From supply chains to value chains: A spotlight on CSR, 2007). Today in the era of globalization, increasing number of companies are operating are going global. These Multinational corporations (MNCs) operate in multicultural, multi-ethnic and geographically distributed systems across the globe running supply chains that span from suppliers’ suppliers to distributors’ distributors. Quite a few of these actors and factors are already located in the developing world and more are being relocated. Many of these MNCsâ⠂¬â„¢ foreign affiliates and arm’s length suppliers thus are governed by different level of CSR procedures.Today, consumers and employees along with pressure from a varied group of stakeholders are holding businesses to perform more on higher and broader social environmental standards than in the past. Besides, in today’s information spread and media stage, companies are not just adjudged by the behaviors of those associated, including sourcing facilities, licenses, agents, partners, and host governments†... Quite a few of these actors and factors are already located in the developing world and more are being relocated. Many of these MNCs’ foreign affiliates and arm’s length suppliers thus are governed by different level of CSR procedures (Bhandarkar & Alvarez-Rivero, From supply chains to value chains: A spotlight on CSR, 2007). Context Today, consumers and employees along with pressure from a varied group of stakeholders are holding businesses to perform more on higher and broader social environmental standards than in the past. Besides, in today’s information spread and media stage, companies are not just adjudged by the behaviors of those associated, including sourcing facilities, licenses, agents, partners, and host governments† (Smith, Gare; Feldman, Dan; The World Bank Group, 2003, p. 1). In addition, business entities, in particular MNCs are not only â€Å"accountable under local law, but also to various norms and standards, promulgated by global agenc ies such as International Labor Organization (ILO), the Universal Declaration of Human Rights (UDHR), and corporate best practices† (Smith, Gare; Feldman, Dan; The World Bank Group, 2003, p. 1). Failure to comply these norms and standards not only can damage reputation of firms’ corporate practices, â€Å"but also may face protests, boycotts, attacks on corporate property, divestment campaigns, hostile shareholders resolutions and the enactment of sanction laws† (Smith, Gare; Feldman, Dan; The World Bank Group, 2003, p. 1). The apparel industry has already faced some of this music in the 1990’s with â€Å"many apparel and footwear firms discovered when they first confronted serious legal and reputational challenges in the 1990s related to allegations of labor abuses in foreign sourcing

DQ # 1 Response to Classmate Research Paper Example | Topics and Well Written Essays - 250 words

DQ # 1 Response to Classmate - Research Paper Example Rita, the remaining staff nurses, and with the help of all employees on the unit can succeed in orienting and retaining the seven new graduates by first welcoming them to the unit.  In helping the new employees feel welcome, it is also important to realize that leadership and followership has a synergistic relationship and that â€Å"no change can occur without willing and committed followers† (Grossman & Valiga, 2009, p. 36). Starting a new job, especially as a new graduate nurse is very stressful. Fear and lack of confidence can sometimes overwhelm a new graduate and it is extremely important to make them feel welcome. Research suggests that when the  Ã¢â‚¬Å"staff is friendly, welcoming, open to the new graduates being there, supportive, and encouraging of their learning† can result in a successful transition from new graduate to nurse (Glynn & Sylva, 2013, p. 177). In real world, it can be seen that through creating quality relationship between leadership and followership, it is possible to orient as well as retain the new nurses. As stated by Grossman and Valiga (2009), â€Å"Leadership and followership are two separate concepts that are complementary or reciprocal, not competitive† (p. 36). People often feel apprehensive when they start a new job but when they are given a warm welcome to the unit, they quickly gain confidence which helps them to acclimatize to the environment. This is so because there would be mutual understanding among the team members which help them to easily fit in the working environment. I have witnessed this at Baptist Hospital where the pre op nurse manager displays quality leadership styles where new nurses are given the opportunity to freely interact with senior nurses in a bid to build confidence in them.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Offering encouragement and support to the new nurses and allowing them to ask questions, makes them feel comfortable and increases their confidence. It is also important to gain feedback from the new

Creativity and Group dynamic Assignment Example | Topics and Well Written Essays - 750 words

Creativity and Group dynamic - Assignment Example When Danny and Rusty set out to find a team for themselves, they were looking for people who were either too smart in what they do, or they thought differently. This team was made up of people who were unique in their own way, yet when they worked together on this plan, they got successful in what no one else could do. Each of the team member was creative is his own way. They all thought of brilliant ideas and carried out the entire plan successfully. They were however different from each other. In one occasion we could see two of the men were acting like gays which annoyed their other team member. There were white men and there were black men, there were Americans and there was even a Chinese, there were 18 year old boys and 50+ year old man as well. What brought success to the team was how they gelled in with each other; how they accepted each other as they are and worked together as a team. What is remarkable about the group dynamics of this team is that how they communicated well with each other and how they knew about the strengths and weaknesses of each other. While working in a team it is very important that you know each other very well; you should know your team member’s strengths and their weaknesses as well. ... Although each member was creative in his own domain, there were obviously some limitations. Some members could not practice their creative ideas because they did not appeal to their other team members. There were also limitations from the environment. While you are working in a group, you have to take decisions that are approved by everyone, especially the leader. You simply cannot practice your creativity without the agreement of you teammates. And this leads to creative thinking in limitations. When creativity is at peak, an individual or group can also innovate new product, service or an idea. In this movie, they innovated new ways of robbery. Although the idea does not bring something new that helps the society, but it did create a new way of completing their mission. Although the movie is about robbery, we could clearly the aspect of creativity and group dynamics in their mission. From the way team was formed, to how Danny led it, to how they carried out all the tasks; it showed a great team where all members had only one focus-to steal the vault’s money. Bibliography Naiman, L. (2010). What is Creativity? Retrieved May 21, 2011, from Creativity at work:

Film Reaction EthicsWag the Dog Movie Review Example | Topics and Well Written Essays - 250 words

Film Reaction EthicsWag the Dog - Movie Review Example Doublespeak is a term that is intentionally used to disguise or distort the actual meaning of words. It makes a situation more pleasant. In the movie "Wag the Dog," Conrad, playing â€Å"Mr. Fix it,† employs the technique of doublespeak to take off the gross appearance of the president’s sex scandal. He diverts the attention of the public to other false war stories, making the situation seem less serious. In the movie, Motss emerges in the media and public belief that the war story is true, while also believing the idea of sex scandal to be true. However, the false war tales overshadow the true sex scandal of the president until he gets re-elected. When Motss tries to let the cat out of the bag, he is killed to keep the truth secrete. The movie is a clear show of how propaganda forms the normal recipe of the political discourse, where politicians use the power to get everything they

Treatment Research for Multiple Myeloma (MM)

Treatment Research for Multiple Myeloma (MM) ABSTRACT INTRODUCTION Multiple myeloma (MM) is a hematological neoplasm that appears after transformation and uncontrolled proliferation of plasma cells. MM is characterized by a heterogeneous genetic aberrations and very different clinical outcomes (Avet-Loiseau, . Boyd KD). Although treatments for MM have increased by develop new and more sophisticated therapeutics drugs such an immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs)( Shaji K. Kumar, Raghupathy, Antonio Palumbo) the marked variability of responses indicate that larger studies will be required. Currently, identification of cytogenetic abnormalities is performed by conventional karyotyping and fluorescence in situ hybridization. However, these disorders are not sufficient to explain the malignant phenotype given that are also observed in premalignant states of MM such a monoclonal gammopathy of unknown significance (MGUS) or smoldering myeloma(SM)(Bergsagel, Hideshima). This finding justifies the need for a comprehensive screening of genetic abnormalities in MM patients, which has not been incorporated in the medical workup yet. Recently, the introduction of massive sequencing of patient genome using next-generation sequencing (NGS) technologies has considerably increased the understanding of the biological features of MM. Many works have described the complex and heterogeneous mutational profile of MM patients(bolli nuevo, walker). Whole Exome Sequency (WES) studies in newly diagnosis MM patients have confirmed that more than 50 genes are mutated in the first manifestation of disease (walker). However, only few genes have been detected recurrently mutated at diagnosis, including KRAS, NRAS, BRAF, DIS3, TP53 and FAM46C, and only TP53 mutations have been recurentelly associated with poor survival. In addition, other studies have assessed the clonal evolution over time, pointing out that systemic treatment with chemotherapy may affect the livelihood of some subclones more than others, and thus may influence the tumor evolution over time(Egan JB, bolli, Keats JJ, ) The introduction of targeted studies allows the detection of mutations even with very low allele frequencies at an affordable price, allowing the incorporation of extensive genetic studies to the clinical workup. In the last years, several groups have applied this approach in order to achieve a better patients stratification and prognosis prediction. Although many studies have highlighted the importance of the subclonal landscape in MM and many efforts have been undertaken to stratify patients and predicts their responses, there is no clear relation between sensitives or refractories clones to treatment, and more information about the prognostic impact of this subclonal profile in series of homogeneously treated MM patients is needed. A large number of clinical trial are being carried out with this aim, unify treatments in order to study more effectively the impact of genetic alterations in prognosis. In this work, newly diagnosis MM patient homogenously treated have been genetically characterized using a combination of the most recent techniques, including FISH and ultra-deep targeted sequencing. We applied the highest read depth described in the literature with the aim to detect minority subclones ignored to date. We also integrated these data with the clinical features to find out new patterns of behavior, relate them with survival and reveal new insight into the complexity of clonal and subclonal architecture of MM. Patient samples Samples were taken from the available 79 newly diagnosed MM patient enrolled in the clinical trial GEM10MAS65 (registered at www.clinicaltrials.gov as #NCT01237249). This is a phase III trial where patients older than 65 years were randomly assigned between two treatments arms: sequential melphalan/prednisone/Velcade (MPV) followed by Revlimid/low dose dexamethasone (Rd) versus alternating melphalan/prednisone/Velcade (MPV) with Revlimid/low dose dexamethasone (Rd). Progression free survival (PFS) and overall survival (OS) were measured from the starting date of the treatment. The median time to progression was 26.4 months with a median follow up of 31.5 months. Targeted sequencing and mutation calling Positive plasma cells CD138 were isolated from bone marrow aspirates and DNA was extracted using AllPrep DNA/RNA mini kit (Quiagen). Only 20 ng of DNA were used to prepare libraries using Ampliseq Library Kit 2.0. We also sequenced DNA from the 15 available CD138 negative fractions in order to filter out potential artifacts and corroborate detection sentivity. Samples were sequenced using Ion Torrent platform (IonProton, Thermofisher, Carlsbad, CA, USA) using the M3P gene panel (Mayo Clinic, Arizona). This panel spreads out over 77 genes frequently mutated in MM, which are related to critical pathophysiological pathways, associated to drug resistance or targetable with molecular drugs [paper mayo kortum etal]. Quality filter and alignments was performed using Torrent Suit software (Life Technologies) Single nucleotide variants were calling and annotated using Ion Reporter software applying in-house modifications in call variants process. Variants listed in Single Nucleotide Polimorph ism database (dbSNP, http://www.ncbi.nlm.nih.gov/SNP/) were excluded from samples without germline available, as well as variants that were detected in multiple samples. In addition, to test the ability of the workflow previously described, we applied a novel bioinformatics pipeline developed by Spanish National Cancer Research Centre (CNIO). All reported mutations were detected by both bioinformatics approaches. The integrative genomic viewer (IGV) was used to visualize the read alignments, single variants and correct sequencing errors due to homopolymer regions. Statistical analysis All statistical analysis was performed using the statistical environment R. Correlation coefficients between mutated genes and cytogenetic aberrations was assessed and plotted using corrplot (https://cran.r-project.org/web/packages/corrplot/). Differences in survival were tested using the log-rank test. Cox proportional hazard regression was employed to obtain hazards ratios (HR) and evaluated at 5% of significance level. A second approach called LASSO (least absolute shrinkage and selection operator) was performed to detect relevant variables among clinical, cytogenetic and mutated genes.   Further details can be found in Data Supplement. RESULTS Mutated genes and altered pathways (cambiar tà ­tulo) We sequenced 79 tumor samples with a mean coverage depth of 1600X. The minimum coverage of the detected variants was 60X and the average coverage 370X. We identified 170 nonsynonymous missense/nonsense/stoploss single variants, 81 of them (48%) were predicted pathogenic by Sift and Polyphen and 61 (36%)   have been described in COSMIC data base.   85% of patients harbored at least 1 mutation with a median of 2.1 mutations per patient. We detected mutations in 53 genes (Figure1), although 6 genes accounted the 39% of the total number of mutations; KRAS= 21.5%, DIS3= 19%, NRAS= 16.5%, BRAF= 10.1%, TP53= 8.8% and ATM= 7.6% of the patients.  Ã‚   48% of patients (38/79) presented at least one mutation in genes envolved in RAS/MAPK pathway, being the most frequently mutated pathway. 72 and 100% of variants in KRAS and NRAS respectively were detected in the hotspot codons 12, 13 and 61, and the targetable V600E BRAF mutation was detected in 1 patient. (Figure 2 supplemental?). NFKB p athway was the second most frequently mutated in our cohort, accounting for the 15% of all mutations distributed in 25 % of the patients (19/79). This pathway included TRAF3 (5 mutations, one nonsense and 4 missense) and TRAF2 (3 missense mutation) all of them predicted pathogenic by Sift and Polyphen. Other pathways importantly altered in the cohort were MYC in 11% of patients (9/79), cereblon and ciclyn both in 9% of patients (7/79). Multiple mutations within the same gene were observed in 11 patients: 4 of whom harbored 2 and 3 mutations within DIS3 (patient 1-24= Glu501Lys and Phe120Leu at 8 and 53 % of VRF, patient 2-236= Asp487His and Asp479Glu at 4 and 21 of VRF respectively, patient 3 321= Tyr753Asn and Glu126Lys at 2 and 58 % of VRF respectively and patient 4-42 = Arg820Trp, Gly249Glu and at 14, 20 and 24% of VRF respectively). Other 2 patients showed 2 and 3 mutation in KRAS (patient 5-168= Gly13Asp and Gln61His at 9 and 13 %of VRF and patient 6-269 = Tyr71Asp, UTR3 in exon 6 and Gln61Glu at 3, 15 and 37 % of VRF respectively; 2 patients with 2 mutation in NRAS(patient 7-177= .Gln61Lys   and Gly12Ala at 5 and 12% of VRF respectively and patient 8-257=   Gln61Glu   and Gly12Ala at 5 and 6% of VRF respectively), one patient with 3 mutations in MAX (patient 9-190= Arg36Lys , Arg35Leu and Glu32Val at 10, 20 and 26 %of VRF), one patient with 3 mutations in TRAF3 (patient 10-40 = Lys453Asn, His136Tyr   and Phe445Leu 8, 11 and1 3% of VRF) and one patient with 2 mutation in TP53 (patient 11-40 = Asp208Val   and Glu204Ter at 35 and 36% of VRF respectively). Variant Read Frequency study The VRF found in our cohort were diverse.   We detected 50% of variants (85/170) below 25% of VRF and 27% (46/170) below 10% (Figure 2). KRAS (n=5) DIS3 (n=5), BRAF (n=4), NRAS (n=4), and TP53 (n=3) were the genes that harbored the largest number of low frequency mutations (Figure 2). KRAS, NRAS, BRAF and TP53 mutations were, in all cases, lower than 50% of VRF while DIS3 showed mutations in a broad range (from 2 to 85%)(Fig3). ). Most of DIS3 mutations with VRF

The Use of Series in The Big Sleep by Raymond Chandler Essay -- sleep

The Use of Series in The Big Sleep by Raymond Chandler In The Big Sleep, Raymond Chandler writes items in a series in almost every paragraph that does not include dialogue, occasions, in the text where Marlowe watches the other character do something like open and close a book or light a cigarette and flick the ash into a tray. When Chandler stops the dialogue to creates a space for Marlowe to record elements in the environment, he constructs sentences that indicate how Marlowe assimilates the information: characters perform three or more acts successively and Marlowe notices every movement, recording it at once. Therefore, Chandler builds sentences that contain as many separate actions as possible to reflect how fast the character performs the act, rather than isolate single actions in single sentences that break the action up. Specifically, Chandler builds sentences with items in a series to reflect continuous motion and mimic the way Marlowe perceives it. Series are economical and fast, pointing to the movement of the cha racter and the way Marlowe thinks. The series occur in paragraphs Marlowe narrates, sections before or after dialogue when Marlowe establishes the scope of the scene or moves the scene along. Chandler uses the construction when he describes the principal action in a scene. For example, chapter 17 opens with a paragraph that includes this sentence: "The boy swung the car over to the box hedge in front of Geiger's house, killed the motor and sat looking straight before him with both hands on the wheel" (99). In the paragraph, Chandler describes the inert environment with one compound sentence and two simple sentences. None of them contain a series. The sentence that ... ...es the scene correctly and as quickly as Marlowe sees it. Chandler does not want to write a text that reminds the reader it is a text. Instead he wants to imitate reality. He wants the reader to follow Marlowe, look over his shoulder, and maintain a constant, attached point-of-view shot of the action. For this reason, Chandler uses series to simulate the rhythm and speed of real action. When a writer like Chandler omits words and replaces them with commas, "ands," and "ors," he makes the sentence concise and speedy. When one reads such a text, she understands two things about the scene: how the character moves and how Marlowe perceives the movement. Chandler is sensitive to the relationship between the text, the reader, reality. So he creates a text that mimics real movement and real thinking. He uses series to carry the reader through the text.

Manage People Performance Essay

It is important when allocating work to ensure that resources are appropriately allocated and that they are available for use as and when they are needed. When drawing up a plan you need to focus on what you want to achieve, what you can do to achieve it and what might happen while you are moving toward achievement. You must consider what will be done, when and how it will be done and by whom. You need to identify and communicate organisational vision and develop a unified sense of direction. You will need to conduct an environmental scanning/analysis. Identify short a long term goals and make sure they are realistic and achievable. You would need to develop with relevant personnel strategies and plans for goal achievement as well as financial plans. These plans would need to be communicated to stakeholders and then implement these plans. During this process you must set appropriate KRA’s and KPI’s and track, monitor and evaluate the procedure. When allocating work, the competencies and availability of staff must be considered so that work is allotted to those who are best equipped to do it. You must consider employee experience, skills, knowledge, understandings and workloads. You must consider checking their understanding and give support and opportunities to ask questions. When allocating work the goals and objectives must be clearly defined so that employees can put them into action plans and achieve these goals. Managers and leaders must take into consideration, the interests of the staff members, their availability and the likely outcomes of involving specific employees. You must also consider resource management. When planning work and allocating tasks to employees and employee groups teams efficiency, productivity, cost management and outcomes must all be considered. When allocating work and drawing up plans you must consider a project plan as it shows a description of what is to be done, when and by whom and what funds are available. It covers the entire set of tasks that a project requires and allocates the different aspects of the project to the employees who are best equipped to produce the required outputs. It shows the major products, milestones, activities and resources required on the project. It is necessary to develop KRA’s and KPI’s that meet the organisations needs because they include clearly defined and achievable goals. They measure progress during the year in terms of identified targets, manage skills development, identify areas for development, contribute to the company’s wealth creation, obtain feedback that allow a change of direction when needed and promote an environment of self management. They point to what needs to be achieved. They indicate areas of current and ongoing success. It is also necessary to develop and implement performance management systems because they enable management to track, monitor and evaluate work to ensure that it is contributing towards the success of the organisation. To have a code of conduct in an organisation is vital because it has rules outlining responsibilities of proper practices for individuals and the organisation. It contains descriptions of the principles, values, standards, and rules of behaviour that guide the decisions, procedures and systems of an organisation in a way that contributes to the welfare of its key stakeholders and respects the rights of all constituents affected by its operations. A code of conduct provides a guide to staff for appropriate behaviour it will impact on the way they do their work and on the performance standards expected of the employees. Regularly monitoring and evaluating the work of employees enables the organisations manager to maintain current knowledge of what is happening, to pinpoint problem areas and to solve problems before they become destructive. Monitoring and evaluating will help achieve the intended outcomes, goals and objectives. Giving feedback and reinforcement to employees and acknowledging good work should be a continuous process. Feedback is the information that is given to people to let them know what they are doing well and what needs to improve. It also lets employees know that their efforts have been noticed. Acknowledging reinforces good work practice/behaviour and encourages us in continuing improvement. It acts as a source of recognition for the contribution made by the employees. Employees whose contribution to improvement processes and organisational success is recognised will be motivated to continue improving and you will have created higher levels of enthusiasm. It is important to acknowledge employees efforts and give feedback because employees who feel ignored and exploited will stop caring about their performance levels and quality. The employee will start underperforming, give poor customer service and relationships in the workplace will become strained. Giving effective feedback, reinforcement and acknowledgment will result in learning, improved competence, observable behavioural change and motivation. It will also make the employee feel valued and encourage good work. It is necessary to have systems in place to manage poor performance because they will help monitor, evaluate and keep track of the performance. Performance issues are most easily addressed and resolved when they are at a low level of difficulty and of short duration. Having systems in place will help you see what is doing well and what isn’t and you will be able to change, address and fix it. Problems that are not addressed might go underground, to represent at a later time at a higher level of disruption and significance. Having systems that manage poor performance in place will lead to improvement in performances. It is necessary to understand the organisations termination policy and the legislation to which it relates because unfair termination or dismissal can lead to consequences of dismissal under unfair dismissal laws. Employees can claim that their dismissal was harsh, unjust or unreasonable and unfair and file a complaint or go to court. Unlawful dismissals are primarily based on discrimination grounds and notice periods.

Manufacturing Technology Essay

In this article, it lists out several manufacturing technologies that set out new and easier processes for not just the workload, but set for an easier lifestyle as well. (summary) The automated systems was best said on my end. Transfer machines, cell phones and other automated devices are used to set a communication establishment upon anyone. It’s all about producing faster and having more efficiency in the industrial world. They also help reduce costs such as a bank you have ATM’s rather than having a clerk or 2 handling your withdrawals and deposits. You also have development of apps. These apps can take pictures of your checks and deposit them from there. Also manage your accounts with transfers and payments. It’s claimed that many human interactions really don’t require the human touch to it, which is true. Transfers of virtual products and or cash don’t need to be manually human handled. The article has been developed this year, which defiantl y will have a fair and accurate perspective on the manufacturing technology that we have in mind now. Timings, R., & Wilkinson, S. (2000). Manufacturing Technology (2nd ed.). 1061-2890, Harlow, Essex: Longman. In this book we come across specific detail about percentage-wise wholes in how much costs were reduced at the time of the startup in manufacturing technology. It claimed that all manufacturing technology orders dropped 20.4% at the start of its creation and then suddenly rose 9.8% later that year. Every year since then there’s been a 3% up raise since the start of it all. Having it being written 15 years ago I am heavily against this book, just due to the fact of how much our technology has advanced. The book shows how transfer machines are being held against in the workload and reducing the efficiency of work from its employees which is just a big key factor in communication. With the advancement in technology this has got to be a joke. Almost all technology is set in touch screen adaptations, faster ram processors, and larger memories to keep companies moving and cost efficient. Blaedel, K. L. â€Å"SciTech Connect: Manufacturing Technology.† SciTech Connect: Manufacturing Technology. USDOE, 1 Feb. 1997. Web. 20 Jan. 2015. This set article claims that there are 4 projects that led to the main movement of manufacturing technology. It details exactly how they got to developing such a vast movement at the time which we could easily set apart from our age having it being published over 10 years ago. It shows exactly how to â€Å"develop an understanding of fundamental fabrication process†. Heap, J. (2004). International Journal of Productivity and Performance Management (Vol. 57, pp. 156-176). Bradford, England: Emerald Group. This book had several findings of out SME’s had an early development progress against productivity and performance management throughout different AMT’s. It shows the different effects in management and what manners they had at the time to reduce operation costs and team efficiency. Acquisition of Manufacturing Technology. (2013). MENA Report, Retrieved from http://search.proquest.com.ezproxy.libproxy.db.erau.edu/docview/1419103734?accountid=27203 Throughout this article we the write to see what acquisitions were involved to establish the different types of manufacturing technology in our more recent industry. Our updated technologies have claimed to make our recent years more cost efficient and productive by over 150%! I am all up with this article because it has its cited facts and it’s only 2 years from our current date, so this would be my most supported article just due to the date it was created. Milgrom, P., & Roberts, J. (1990). The Economics of Modern Manufacturing: Technology, strategy, and organization. The American Economic Review, 511-528. In this scholarly article, we learn the economics of modern manufacturing and what came with the update at the time and how it was processed and underwent a revolution. The scholarly article stated that the â€Å"mass production model is being replaced by a vision of a flexible multiproduct firm that emphasizes quality and speedy response to market conditions while utilizing technologically advanced equipment and new forms of organization.† This was the start of a new branch in observing what could be replaced and updated with technology. I do enjoy seeing the central difference of how technology has shaped the workplace with time. Doms, M., Dunne, T., & Roberts, M. J. (1995). The Role of Technology Use in the Survival and Growth of Manufacturing Plants. International Journal of Industrial Organization, 13(4), 523-542. In this scholarly article, we come to distinguish the relationship between principal strength, how we use to come across the usage of manufacturing technology and what growth rates it came with. It stated that the main findings at the time had a mindset of higher progression rates against technology would have a far less development and production failure. Tracey, M., Vonderembse, M. A., & Lim, J. S. (1999). Manufacturing Technology and Strategy Formulation: Keys to Enhancing Competitiveness and Improving Performance. Journal of Operations Management, 17(4), 411-428. When coming across this article we see how the main set of technology was set and how that generation at the time had evolved it into a more competitive and healthier implement. As stated, â€Å"Linear Structural Equation Analysis results show that the relationships between a firm’s practices in these two areas and its competitive capabilities are found to be statistically significant and positive†, which shows me they had their own strategic role in which they followed to test out their performance and which ways they could use to improve the marketing satisfaction. Shepherd, D. A., Mcdermott, C., & Stock, G. N. (2000). Advanced Manufacturing Technology. Journal of High Technology Management Research, 11(1), 19-33. doi:10.1016/S1047- 8310(00)00019-5 We come to the instruction of AMT’s and how their benefits improved our workload and consumer satisfaction. This article shows the specific studies in how AMT’s were tested and outweighed the beneficial manufacturing firms in all over the world. The flexibility and higher efficiency claims from them outsourced many operational downfalls to provide advantage across the marketplace. Cho, K. (1993). Manufacturing Technology in Korea. Journal of Manufacturing Systems, 12(3), 216-222. doi:10.1016/0278-6125(93)90331-M Set across this article we have a different perspective having most of us live in the United States. With 32 set studies across this article it has been set that they have had an establishment of implementing local manufacturers across the nation with the support of  education al programs in technology and engineering. A different set perspective against the U.S. showing us how other countries had a different goal with maintaining manufacturing technology. Anonymous. (2011, ). TECHNOLOGY MANUFACTURING HEALTH CARE. Daily Herald (Arlington Heights, IL) This article was interesting to me to see the perspective of how manufacturing technology affected the health care industry. With 2 new hospitals opening up in other countries, hospitals have set out ads over the radio and television to help drivers understand the dangers of texting while driving and the rising amount of drivers ending up in the hospital from being distracted behind the wheel. I did enjoy reading this because I do commute 80 miles a day to work on the highway and easily see how much people are distracted behind the wheel. I wouldn’t know this new advancement in technology has caused such an uprise in car accidents, enough to open new hospitals around the world.