Creativity and Group dynamic Assignment Example | Topics and Well Written Essays - 750 words

Creativity and Group dynamic - Assignment Example When Danny and Rusty set out to find a team for themselves, they were looking for people who were either too smart in what they do, or they thought differently. This team was made up of people who were unique in their own way, yet when they worked together on this plan, they got successful in what no one else could do. Each of the team member was creative is his own way. They all thought of brilliant ideas and carried out the entire plan successfully. They were however different from each other. In one occasion we could see two of the men were acting like gays which annoyed their other team member. There were white men and there were black men, there were Americans and there was even a Chinese, there were 18 year old boys and 50+ year old man as well. What brought success to the team was how they gelled in with each other; how they accepted each other as they are and worked together as a team. What is remarkable about the group dynamics of this team is that how they communicated well with each other and how they knew about the strengths and weaknesses of each other. While working in a team it is very important that you know each other very well; you should know your team member’s strengths and their weaknesses as well. ... Although each member was creative in his own domain, there were obviously some limitations. Some members could not practice their creative ideas because they did not appeal to their other team members. There were also limitations from the environment. While you are working in a group, you have to take decisions that are approved by everyone, especially the leader. You simply cannot practice your creativity without the agreement of you teammates. And this leads to creative thinking in limitations. When creativity is at peak, an individual or group can also innovate new product, service or an idea. In this movie, they innovated new ways of robbery. Although the idea does not bring something new that helps the society, but it did create a new way of completing their mission. Although the movie is about robbery, we could clearly the aspect of creativity and group dynamics in their mission. From the way team was formed, to how Danny led it, to how they carried out all the tasks; it showed a great team where all members had only one focus-to steal the vault’s money. Bibliography Naiman, L. (2010). What is Creativity? Retrieved May 21, 2011, from Creativity at work:

Film Reaction EthicsWag the Dog Movie Review Example | Topics and Well Written Essays - 250 words

Film Reaction EthicsWag the Dog - Movie Review Example Doublespeak is a term that is intentionally used to disguise or distort the actual meaning of words. It makes a situation more pleasant. In the movie "Wag the Dog," Conrad, playing â€Å"Mr. Fix it,† employs the technique of doublespeak to take off the gross appearance of the president’s sex scandal. He diverts the attention of the public to other false war stories, making the situation seem less serious. In the movie, Motss emerges in the media and public belief that the war story is true, while also believing the idea of sex scandal to be true. However, the false war tales overshadow the true sex scandal of the president until he gets re-elected. When Motss tries to let the cat out of the bag, he is killed to keep the truth secrete. The movie is a clear show of how propaganda forms the normal recipe of the political discourse, where politicians use the power to get everything they

Treatment Research for Multiple Myeloma (MM)

Treatment Research for Multiple Myeloma (MM) ABSTRACT INTRODUCTION Multiple myeloma (MM) is a hematological neoplasm that appears after transformation and uncontrolled proliferation of plasma cells. MM is characterized by a heterogeneous genetic aberrations and very different clinical outcomes (Avet-Loiseau, . Boyd KD). Although treatments for MM have increased by develop new and more sophisticated therapeutics drugs such an immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs)( Shaji K. Kumar, Raghupathy, Antonio Palumbo) the marked variability of responses indicate that larger studies will be required. Currently, identification of cytogenetic abnormalities is performed by conventional karyotyping and fluorescence in situ hybridization. However, these disorders are not sufficient to explain the malignant phenotype given that are also observed in premalignant states of MM such a monoclonal gammopathy of unknown significance (MGUS) or smoldering myeloma(SM)(Bergsagel, Hideshima). This finding justifies the need for a comprehensive screening of genetic abnormalities in MM patients, which has not been incorporated in the medical workup yet. Recently, the introduction of massive sequencing of patient genome using next-generation sequencing (NGS) technologies has considerably increased the understanding of the biological features of MM. Many works have described the complex and heterogeneous mutational profile of MM patients(bolli nuevo, walker). Whole Exome Sequency (WES) studies in newly diagnosis MM patients have confirmed that more than 50 genes are mutated in the first manifestation of disease (walker). However, only few genes have been detected recurrently mutated at diagnosis, including KRAS, NRAS, BRAF, DIS3, TP53 and FAM46C, and only TP53 mutations have been recurentelly associated with poor survival. In addition, other studies have assessed the clonal evolution over time, pointing out that systemic treatment with chemotherapy may affect the livelihood of some subclones more than others, and thus may influence the tumor evolution over time(Egan JB, bolli, Keats JJ, ) The introduction of targeted studies allows the detection of mutations even with very low allele frequencies at an affordable price, allowing the incorporation of extensive genetic studies to the clinical workup. In the last years, several groups have applied this approach in order to achieve a better patients stratification and prognosis prediction. Although many studies have highlighted the importance of the subclonal landscape in MM and many efforts have been undertaken to stratify patients and predicts their responses, there is no clear relation between sensitives or refractories clones to treatment, and more information about the prognostic impact of this subclonal profile in series of homogeneously treated MM patients is needed. A large number of clinical trial are being carried out with this aim, unify treatments in order to study more effectively the impact of genetic alterations in prognosis. In this work, newly diagnosis MM patient homogenously treated have been genetically characterized using a combination of the most recent techniques, including FISH and ultra-deep targeted sequencing. We applied the highest read depth described in the literature with the aim to detect minority subclones ignored to date. We also integrated these data with the clinical features to find out new patterns of behavior, relate them with survival and reveal new insight into the complexity of clonal and subclonal architecture of MM. Patient samples Samples were taken from the available 79 newly diagnosed MM patient enrolled in the clinical trial GEM10MAS65 (registered at www.clinicaltrials.gov as #NCT01237249). This is a phase III trial where patients older than 65 years were randomly assigned between two treatments arms: sequential melphalan/prednisone/Velcade (MPV) followed by Revlimid/low dose dexamethasone (Rd) versus alternating melphalan/prednisone/Velcade (MPV) with Revlimid/low dose dexamethasone (Rd). Progression free survival (PFS) and overall survival (OS) were measured from the starting date of the treatment. The median time to progression was 26.4 months with a median follow up of 31.5 months. Targeted sequencing and mutation calling Positive plasma cells CD138 were isolated from bone marrow aspirates and DNA was extracted using AllPrep DNA/RNA mini kit (Quiagen). Only 20 ng of DNA were used to prepare libraries using Ampliseq Library Kit 2.0. We also sequenced DNA from the 15 available CD138 negative fractions in order to filter out potential artifacts and corroborate detection sentivity. Samples were sequenced using Ion Torrent platform (IonProton, Thermofisher, Carlsbad, CA, USA) using the M3P gene panel (Mayo Clinic, Arizona). This panel spreads out over 77 genes frequently mutated in MM, which are related to critical pathophysiological pathways, associated to drug resistance or targetable with molecular drugs [paper mayo kortum etal]. Quality filter and alignments was performed using Torrent Suit software (Life Technologies) Single nucleotide variants were calling and annotated using Ion Reporter software applying in-house modifications in call variants process. Variants listed in Single Nucleotide Polimorph ism database (dbSNP, http://www.ncbi.nlm.nih.gov/SNP/) were excluded from samples without germline available, as well as variants that were detected in multiple samples. In addition, to test the ability of the workflow previously described, we applied a novel bioinformatics pipeline developed by Spanish National Cancer Research Centre (CNIO). All reported mutations were detected by both bioinformatics approaches. The integrative genomic viewer (IGV) was used to visualize the read alignments, single variants and correct sequencing errors due to homopolymer regions. Statistical analysis All statistical analysis was performed using the statistical environment R. Correlation coefficients between mutated genes and cytogenetic aberrations was assessed and plotted using corrplot (https://cran.r-project.org/web/packages/corrplot/). Differences in survival were tested using the log-rank test. Cox proportional hazard regression was employed to obtain hazards ratios (HR) and evaluated at 5% of significance level. A second approach called LASSO (least absolute shrinkage and selection operator) was performed to detect relevant variables among clinical, cytogenetic and mutated genes.   Further details can be found in Data Supplement. RESULTS Mutated genes and altered pathways (cambiar tà ­tulo) We sequenced 79 tumor samples with a mean coverage depth of 1600X. The minimum coverage of the detected variants was 60X and the average coverage 370X. We identified 170 nonsynonymous missense/nonsense/stoploss single variants, 81 of them (48%) were predicted pathogenic by Sift and Polyphen and 61 (36%)   have been described in COSMIC data base.   85% of patients harbored at least 1 mutation with a median of 2.1 mutations per patient. We detected mutations in 53 genes (Figure1), although 6 genes accounted the 39% of the total number of mutations; KRAS= 21.5%, DIS3= 19%, NRAS= 16.5%, BRAF= 10.1%, TP53= 8.8% and ATM= 7.6% of the patients.  Ã‚   48% of patients (38/79) presented at least one mutation in genes envolved in RAS/MAPK pathway, being the most frequently mutated pathway. 72 and 100% of variants in KRAS and NRAS respectively were detected in the hotspot codons 12, 13 and 61, and the targetable V600E BRAF mutation was detected in 1 patient. (Figure 2 supplemental?). NFKB p athway was the second most frequently mutated in our cohort, accounting for the 15% of all mutations distributed in 25 % of the patients (19/79). This pathway included TRAF3 (5 mutations, one nonsense and 4 missense) and TRAF2 (3 missense mutation) all of them predicted pathogenic by Sift and Polyphen. Other pathways importantly altered in the cohort were MYC in 11% of patients (9/79), cereblon and ciclyn both in 9% of patients (7/79). Multiple mutations within the same gene were observed in 11 patients: 4 of whom harbored 2 and 3 mutations within DIS3 (patient 1-24= Glu501Lys and Phe120Leu at 8 and 53 % of VRF, patient 2-236= Asp487His and Asp479Glu at 4 and 21 of VRF respectively, patient 3 321= Tyr753Asn and Glu126Lys at 2 and 58 % of VRF respectively and patient 4-42 = Arg820Trp, Gly249Glu and at 14, 20 and 24% of VRF respectively). Other 2 patients showed 2 and 3 mutation in KRAS (patient 5-168= Gly13Asp and Gln61His at 9 and 13 %of VRF and patient 6-269 = Tyr71Asp, UTR3 in exon 6 and Gln61Glu at 3, 15 and 37 % of VRF respectively; 2 patients with 2 mutation in NRAS(patient 7-177= .Gln61Lys   and Gly12Ala at 5 and 12% of VRF respectively and patient 8-257=   Gln61Glu   and Gly12Ala at 5 and 6% of VRF respectively), one patient with 3 mutations in MAX (patient 9-190= Arg36Lys , Arg35Leu and Glu32Val at 10, 20 and 26 %of VRF), one patient with 3 mutations in TRAF3 (patient 10-40 = Lys453Asn, His136Tyr   and Phe445Leu 8, 11 and1 3% of VRF) and one patient with 2 mutation in TP53 (patient 11-40 = Asp208Val   and Glu204Ter at 35 and 36% of VRF respectively). Variant Read Frequency study The VRF found in our cohort were diverse.   We detected 50% of variants (85/170) below 25% of VRF and 27% (46/170) below 10% (Figure 2). KRAS (n=5) DIS3 (n=5), BRAF (n=4), NRAS (n=4), and TP53 (n=3) were the genes that harbored the largest number of low frequency mutations (Figure 2). KRAS, NRAS, BRAF and TP53 mutations were, in all cases, lower than 50% of VRF while DIS3 showed mutations in a broad range (from 2 to 85%)(Fig3). ). Most of DIS3 mutations with VRF

The Use of Series in The Big Sleep by Raymond Chandler Essay -- sleep

The Use of Series in The Big Sleep by Raymond Chandler In The Big Sleep, Raymond Chandler writes items in a series in almost every paragraph that does not include dialogue, occasions, in the text where Marlowe watches the other character do something like open and close a book or light a cigarette and flick the ash into a tray. When Chandler stops the dialogue to creates a space for Marlowe to record elements in the environment, he constructs sentences that indicate how Marlowe assimilates the information: characters perform three or more acts successively and Marlowe notices every movement, recording it at once. Therefore, Chandler builds sentences that contain as many separate actions as possible to reflect how fast the character performs the act, rather than isolate single actions in single sentences that break the action up. Specifically, Chandler builds sentences with items in a series to reflect continuous motion and mimic the way Marlowe perceives it. Series are economical and fast, pointing to the movement of the cha racter and the way Marlowe thinks. The series occur in paragraphs Marlowe narrates, sections before or after dialogue when Marlowe establishes the scope of the scene or moves the scene along. Chandler uses the construction when he describes the principal action in a scene. For example, chapter 17 opens with a paragraph that includes this sentence: "The boy swung the car over to the box hedge in front of Geiger's house, killed the motor and sat looking straight before him with both hands on the wheel" (99). In the paragraph, Chandler describes the inert environment with one compound sentence and two simple sentences. None of them contain a series. The sentence that ... ...es the scene correctly and as quickly as Marlowe sees it. Chandler does not want to write a text that reminds the reader it is a text. Instead he wants to imitate reality. He wants the reader to follow Marlowe, look over his shoulder, and maintain a constant, attached point-of-view shot of the action. For this reason, Chandler uses series to simulate the rhythm and speed of real action. When a writer like Chandler omits words and replaces them with commas, "ands," and "ors," he makes the sentence concise and speedy. When one reads such a text, she understands two things about the scene: how the character moves and how Marlowe perceives the movement. Chandler is sensitive to the relationship between the text, the reader, reality. So he creates a text that mimics real movement and real thinking. He uses series to carry the reader through the text.

Manage People Performance Essay

It is important when allocating work to ensure that resources are appropriately allocated and that they are available for use as and when they are needed. When drawing up a plan you need to focus on what you want to achieve, what you can do to achieve it and what might happen while you are moving toward achievement. You must consider what will be done, when and how it will be done and by whom. You need to identify and communicate organisational vision and develop a unified sense of direction. You will need to conduct an environmental scanning/analysis. Identify short a long term goals and make sure they are realistic and achievable. You would need to develop with relevant personnel strategies and plans for goal achievement as well as financial plans. These plans would need to be communicated to stakeholders and then implement these plans. During this process you must set appropriate KRA’s and KPI’s and track, monitor and evaluate the procedure. When allocating work, the competencies and availability of staff must be considered so that work is allotted to those who are best equipped to do it. You must consider employee experience, skills, knowledge, understandings and workloads. You must consider checking their understanding and give support and opportunities to ask questions. When allocating work the goals and objectives must be clearly defined so that employees can put them into action plans and achieve these goals. Managers and leaders must take into consideration, the interests of the staff members, their availability and the likely outcomes of involving specific employees. You must also consider resource management. When planning work and allocating tasks to employees and employee groups teams efficiency, productivity, cost management and outcomes must all be considered. When allocating work and drawing up plans you must consider a project plan as it shows a description of what is to be done, when and by whom and what funds are available. It covers the entire set of tasks that a project requires and allocates the different aspects of the project to the employees who are best equipped to produce the required outputs. It shows the major products, milestones, activities and resources required on the project. It is necessary to develop KRA’s and KPI’s that meet the organisations needs because they include clearly defined and achievable goals. They measure progress during the year in terms of identified targets, manage skills development, identify areas for development, contribute to the company’s wealth creation, obtain feedback that allow a change of direction when needed and promote an environment of self management. They point to what needs to be achieved. They indicate areas of current and ongoing success. It is also necessary to develop and implement performance management systems because they enable management to track, monitor and evaluate work to ensure that it is contributing towards the success of the organisation. To have a code of conduct in an organisation is vital because it has rules outlining responsibilities of proper practices for individuals and the organisation. It contains descriptions of the principles, values, standards, and rules of behaviour that guide the decisions, procedures and systems of an organisation in a way that contributes to the welfare of its key stakeholders and respects the rights of all constituents affected by its operations. A code of conduct provides a guide to staff for appropriate behaviour it will impact on the way they do their work and on the performance standards expected of the employees. Regularly monitoring and evaluating the work of employees enables the organisations manager to maintain current knowledge of what is happening, to pinpoint problem areas and to solve problems before they become destructive. Monitoring and evaluating will help achieve the intended outcomes, goals and objectives. Giving feedback and reinforcement to employees and acknowledging good work should be a continuous process. Feedback is the information that is given to people to let them know what they are doing well and what needs to improve. It also lets employees know that their efforts have been noticed. Acknowledging reinforces good work practice/behaviour and encourages us in continuing improvement. It acts as a source of recognition for the contribution made by the employees. Employees whose contribution to improvement processes and organisational success is recognised will be motivated to continue improving and you will have created higher levels of enthusiasm. It is important to acknowledge employees efforts and give feedback because employees who feel ignored and exploited will stop caring about their performance levels and quality. The employee will start underperforming, give poor customer service and relationships in the workplace will become strained. Giving effective feedback, reinforcement and acknowledgment will result in learning, improved competence, observable behavioural change and motivation. It will also make the employee feel valued and encourage good work. It is necessary to have systems in place to manage poor performance because they will help monitor, evaluate and keep track of the performance. Performance issues are most easily addressed and resolved when they are at a low level of difficulty and of short duration. Having systems in place will help you see what is doing well and what isn’t and you will be able to change, address and fix it. Problems that are not addressed might go underground, to represent at a later time at a higher level of disruption and significance. Having systems that manage poor performance in place will lead to improvement in performances. It is necessary to understand the organisations termination policy and the legislation to which it relates because unfair termination or dismissal can lead to consequences of dismissal under unfair dismissal laws. Employees can claim that their dismissal was harsh, unjust or unreasonable and unfair and file a complaint or go to court. Unlawful dismissals are primarily based on discrimination grounds and notice periods.

Manufacturing Technology Essay

In this article, it lists out several manufacturing technologies that set out new and easier processes for not just the workload, but set for an easier lifestyle as well. (summary) The automated systems was best said on my end. Transfer machines, cell phones and other automated devices are used to set a communication establishment upon anyone. It’s all about producing faster and having more efficiency in the industrial world. They also help reduce costs such as a bank you have ATM’s rather than having a clerk or 2 handling your withdrawals and deposits. You also have development of apps. These apps can take pictures of your checks and deposit them from there. Also manage your accounts with transfers and payments. It’s claimed that many human interactions really don’t require the human touch to it, which is true. Transfers of virtual products and or cash don’t need to be manually human handled. The article has been developed this year, which defiantl y will have a fair and accurate perspective on the manufacturing technology that we have in mind now. Timings, R., & Wilkinson, S. (2000). Manufacturing Technology (2nd ed.). 1061-2890, Harlow, Essex: Longman. In this book we come across specific detail about percentage-wise wholes in how much costs were reduced at the time of the startup in manufacturing technology. It claimed that all manufacturing technology orders dropped 20.4% at the start of its creation and then suddenly rose 9.8% later that year. Every year since then there’s been a 3% up raise since the start of it all. Having it being written 15 years ago I am heavily against this book, just due to the fact of how much our technology has advanced. The book shows how transfer machines are being held against in the workload and reducing the efficiency of work from its employees which is just a big key factor in communication. With the advancement in technology this has got to be a joke. Almost all technology is set in touch screen adaptations, faster ram processors, and larger memories to keep companies moving and cost efficient. Blaedel, K. L. â€Å"SciTech Connect: Manufacturing Technology.† SciTech Connect: Manufacturing Technology. USDOE, 1 Feb. 1997. Web. 20 Jan. 2015. This set article claims that there are 4 projects that led to the main movement of manufacturing technology. It details exactly how they got to developing such a vast movement at the time which we could easily set apart from our age having it being published over 10 years ago. It shows exactly how to â€Å"develop an understanding of fundamental fabrication process†. Heap, J. (2004). International Journal of Productivity and Performance Management (Vol. 57, pp. 156-176). Bradford, England: Emerald Group. This book had several findings of out SME’s had an early development progress against productivity and performance management throughout different AMT’s. It shows the different effects in management and what manners they had at the time to reduce operation costs and team efficiency. Acquisition of Manufacturing Technology. (2013). MENA Report, Retrieved from http://search.proquest.com.ezproxy.libproxy.db.erau.edu/docview/1419103734?accountid=27203 Throughout this article we the write to see what acquisitions were involved to establish the different types of manufacturing technology in our more recent industry. Our updated technologies have claimed to make our recent years more cost efficient and productive by over 150%! I am all up with this article because it has its cited facts and it’s only 2 years from our current date, so this would be my most supported article just due to the date it was created. Milgrom, P., & Roberts, J. (1990). The Economics of Modern Manufacturing: Technology, strategy, and organization. The American Economic Review, 511-528. In this scholarly article, we learn the economics of modern manufacturing and what came with the update at the time and how it was processed and underwent a revolution. The scholarly article stated that the â€Å"mass production model is being replaced by a vision of a flexible multiproduct firm that emphasizes quality and speedy response to market conditions while utilizing technologically advanced equipment and new forms of organization.† This was the start of a new branch in observing what could be replaced and updated with technology. I do enjoy seeing the central difference of how technology has shaped the workplace with time. Doms, M., Dunne, T., & Roberts, M. J. (1995). The Role of Technology Use in the Survival and Growth of Manufacturing Plants. International Journal of Industrial Organization, 13(4), 523-542. In this scholarly article, we come to distinguish the relationship between principal strength, how we use to come across the usage of manufacturing technology and what growth rates it came with. It stated that the main findings at the time had a mindset of higher progression rates against technology would have a far less development and production failure. Tracey, M., Vonderembse, M. A., & Lim, J. S. (1999). Manufacturing Technology and Strategy Formulation: Keys to Enhancing Competitiveness and Improving Performance. Journal of Operations Management, 17(4), 411-428. When coming across this article we see how the main set of technology was set and how that generation at the time had evolved it into a more competitive and healthier implement. As stated, â€Å"Linear Structural Equation Analysis results show that the relationships between a firm’s practices in these two areas and its competitive capabilities are found to be statistically significant and positive†, which shows me they had their own strategic role in which they followed to test out their performance and which ways they could use to improve the marketing satisfaction. Shepherd, D. A., Mcdermott, C., & Stock, G. N. (2000). Advanced Manufacturing Technology. Journal of High Technology Management Research, 11(1), 19-33. doi:10.1016/S1047- 8310(00)00019-5 We come to the instruction of AMT’s and how their benefits improved our workload and consumer satisfaction. This article shows the specific studies in how AMT’s were tested and outweighed the beneficial manufacturing firms in all over the world. The flexibility and higher efficiency claims from them outsourced many operational downfalls to provide advantage across the marketplace. Cho, K. (1993). Manufacturing Technology in Korea. Journal of Manufacturing Systems, 12(3), 216-222. doi:10.1016/0278-6125(93)90331-M Set across this article we have a different perspective having most of us live in the United States. With 32 set studies across this article it has been set that they have had an establishment of implementing local manufacturers across the nation with the support of  education al programs in technology and engineering. A different set perspective against the U.S. showing us how other countries had a different goal with maintaining manufacturing technology. Anonymous. (2011, ). TECHNOLOGY MANUFACTURING HEALTH CARE. Daily Herald (Arlington Heights, IL) This article was interesting to me to see the perspective of how manufacturing technology affected the health care industry. With 2 new hospitals opening up in other countries, hospitals have set out ads over the radio and television to help drivers understand the dangers of texting while driving and the rising amount of drivers ending up in the hospital from being distracted behind the wheel. I did enjoy reading this because I do commute 80 miles a day to work on the highway and easily see how much people are distracted behind the wheel. I wouldn’t know this new advancement in technology has caused such an uprise in car accidents, enough to open new hospitals around the world.